One of the most important aspects of scientific research is the ability to understand and even perfect the naturally occurring hormones and peptides in the body and actually improve their functioning. CJC1295 is a good example of this type of research. CJC1295 is an analog, a synthetically produced peptide that enhances the functions of the GHRH, growth hormone-releasing hormone within the cells both in the body and in laboratory studies.
CJC1295 is just a small peptide hormone containing just 30 amino acids. Like growth hormone-releasing hormone it acts on the cells of the anterior pituitary to simulate the release of growth hormone. Growth hormone has been studied both in vitro and in vivo research and its effects on muscle growth, metabolism and body systems are well documented.
Bioconjugation
One of the very unique aspects of CJC1295 is that it has the ability to bind with other biomolecules and link in a stable configuration. The biomolecule that CJC1295 links with most often is another naturally occurring protein called albumin. Albumin is found in the blood plasma and, when it binds or links with CJC1295, it actually protects the CJC1295 from the natural enzymes in the body that are designed to break down the CJC1295 peptide.
This creates a type of synergy where the two biomolecules are stronger and more effective at their respective functions that if they were not bound together. In the case of CJC1295 it is much longer acting in the cells, trigger a sustained and more significant stimulation of the cells of the anterior pituitary. In turn more growth hormone is produced by the cells in laboratory studies, showing that the bioconjugation factor is essential to the long half-life of this analog when compared to naturally occurring GHRH.
GRF Receptor Activation
In a 2005 study published in “Endocrinology” it was reported in an extensive study that in rat pituitary tests, the use of CJC1295 that was bioconjugated resulted in a 4 fold increase in GH levels for two hours over other derivatives of GH-releasing factor. It was also found to extend the half-life of plasma and increased the presence of albumin circulating in the plasma beyond the 24 hour mark.
